Joe Palooka is a naive young man whose father Pete was a champion boxer, but his lifestyle caused Joe's mother Mayme to leave him and to take young Joe to the country to raise him.

Claghorn gets into some financial difficulties and is forced by a machine-political gang to enter a race for state senator against his wife (Una Merkel) who appears to have a good chance to beat the political hack backed by the machine. Claghorn is in to siphon votes and ensure his wife's opponent will win and is expected to run a campaign that will defeat himself and his wife. But, he runs to win and the machine's henchies abduct him.

Underworld king Lee Lother has been killed aboard a ocean liner, several people could have been the murderer. There is his mistress Anya Roysen, a married woman, who was jealous of his flirtations with his old moll, night club singer Sally Marsh, who had agreed for one last night with Lother, to get her younger brother Ned out of the Lother's clutches because he has faked Lother's name on a check to pay his gambling debts. Then there is Sally's new flame Jimmy Brett, a con man and gentlemen thief, who has out-tricked Lother in a fixed poker game, and is, together with shorty, after the ladies jewels. Inspector McKinney suspects Joe Saunders, a recently released convict, who was arrested due to some tips by Lother, but Ned and Sally insist that they committed the crime alone.