Frank Johnson, a sole witness to a gangland murder, goes into hiding and is trailed by Police Inspector Ferris, on the theory that Frank is trying to escape from possible retaliation. Frank's wife, Eleanor, suspects he is actually running away from their unsuccessful marriage. Aided by a newspaperman, Danny Leggett, Eleanor sets out to locate her husband. The killer is also looking for him, and keeps close tabs on Eleanor.

A Japanese man claiming to be Mr. Moto, of the International Police, is abducted and murdered soon after disembarking from a ship at Port Said in Egypt. The real Mr. Moto is already in Port Said, investigating a conspiracy against the British and French governments.

Jo March and her husband Professor Bhaer operate the Plumfield School for poor boys. When Dan, a tough street kid, comes to the school, he wins Jo's heart despite his hard edge, and she defends him when he is falsely accused. Dan's foster father, Major Burdle, is a swindler in cahoots with another crook called Willie the Fox. When the Plumfield School becomes in danger of foreclosure, the two con men cook up a scheme to save the home.